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Related Experiment Video

Updated: Jun 12, 2026

Electrospinning Growth Factor Releasing Microspheres into Fibrous Scaffolds

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Published on: August 16, 2014

Electrosprayed core-shell microspheres for protein delivery.

Yiquan Wu¹, I-Chien Liao, Scott J Kennedy

¹Materials Science Program, Department of Mechanical Engineering, University of Rochester, Rochester, New York 14627, USA. wuyiquan@me.rochester.edu

Chemical Communications (Cambridge, England)

|May 21, 2010

Summary

This summary is machine-generated.

A novel electrospraying method creates core-shell microspheres (CSMs) for controlled protein delivery. These protein-loaded CSMs demonstrate steady release over three weeks, avoiding initial burst release.

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Area of Science:

Biomaterials Science
Drug Delivery Systems
Polymer Chemistry

Background:

Controlled release drug delivery systems are crucial for therapeutic efficacy.
Microsphere formulations offer advantages in encapsulating and delivering therapeutic proteins.
Biodegradable polymers are desirable for safe and effective in vivo applications.

Purpose of the Study:

To develop a single-step electrospraying technique for fabricating protein-loaded core-shell microspheres (CSMs).
To characterize the protein release kinetics from the developed CSMs.
To evaluate the potential of these CSMs for sustained protein delivery.

Main Methods:

A single-step electrospraying process was employed to generate CSMs.
Protein was encapsulated as the core, and an amphiphilic biodegradable polymer formed the shell.
In vitro protein release studies were conducted over a three-week period.

Main Results:

The electrospraying technique successfully produced CSMs with a distinct core-shell structure.
Protein release profiles exhibited steady kinetics over the 3-week study duration.
No significant initial burst release of the encapsulated protein was observed.

Conclusions:

The developed electrospraying method provides an efficient route to fabricate protein-loaded CSMs.
The CSMs demonstrate excellent potential for sustained and controlled protein release applications.
This technique offers a promising platform for advanced drug delivery systems.