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Bone mineral density in HIV-infected women taking antiretroviral therapy: a systematic review

Erico Higino de Carvalho1, Thais Gelenske, Francisco Bandeira

  • 1Instituto de Medicina Integral Professor Fernando Figueira, Recife, PE, Brasil. ericohc@hotmail.com <ericohc@hotmail.com>

Arquivos Brasileiros De Endocrinologia E Metabologia
|May 21, 2010
PubMed

Insights

Antiretroviral therapy (ART) is linked to lower bone mineral density (BMD) at the femoral neck in HIV-positive women. More research is needed to understand osteoporosis and fracture risks in this population.

Area of Science:

  • Medical Science
  • Infectious Diseases
  • Bone Health

Background:

  • Osteoporosis is common in HIV-infected individuals, affecting both men and women.
  • Antiretroviral therapy (ART) is suspected to contribute to osteoporosis development in HIV patients.
  • The specific impact of ART on bone health and fracture risk in HIV-positive women remains unclear.

Purpose of the Study:

  • To systematically review the literature on bone loss, bone mineral density (BMD), and fractures in HIV-positive women using ART or protease inhibitors (PI).

Main Methods:

  • A systematic review of five studies was conducted after screening 597 citations from PubMed, EMBASE, and Lilacs.
  • The review focused on evaluating BMD and fracture data in HIV-positive women on ART/PI therapy.

Main Results:

  • A significant difference of over 3% in femoral neck BMD was observed in HIV-positive women using PI/ART compared to non-users.
  • No significant difference in lumbar spine BMD was found between ART/PI users and non-users.
  • Insufficient data prevented conclusions regarding fracture occurrence in this cohort.

Conclusions:

  • PI/ART use is associated with reduced femoral neck BMD in HIV-positive women.
  • Further research is essential to elucidate the relationship between ART, osteoporosis, and fracture risk in HIV-positive women.

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