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Coagulopathy parameters in patients with Crimean-Congo hemorrhagic fever and its relation with mortality

P Onguru1, S Dagdas, H Bodur

  • 1Department of Infectious Diseases and Clinical Microbiology, Numune Education and Research Hospital, Ankara, Turkey. pinaronguru1@yahoo.com

Journal of Clinical Laboratory Analysis
|May 21, 2010
PubMed

Insights

Classic coagulopathy markers like platelet count and activated partial thromboplastin time (aPTT) are key for monitoring Crimean-Congo hemorrhagic fever (CCHF) mortality. Other markers such as protein C and S do not significantly predict outcomes in CCHF patients.

Area of Science:

  • Medical Research
  • Infectious Diseases
  • Hematology

Background:

  • Crimean-Congo hemorrhagic fever (CCHF) is a severe systemic illness with significant bleeding risks.
  • Key CCHF manifestations include ecchymosis, visceral bleeding, and liver dysfunction.
  • Understanding coagulopathy markers is crucial for managing CCHF patients.

Purpose of the Study:

  • To investigate the profile of various coagulopathy markers in CCHF patients.
  • To determine the clinical significance of these markers in predicting CCHF mortality.
  • To assess the utility of different laboratory tests in CCHF patient follow-up.

Main Methods:

  • A cohort of 83 CCHF patients was studied.
  • Coagulopathy markers were analyzed, including platelet count, PT, aPTT, INR, fibrinogen, protein C, protein S, antithrombin III, APCR, and D-dimer.
  • Fatal CCHF cases were compared with nonfatal cases to identify prognostic factors.

Main Results:

  • Platelet count, PT, aPTT, INR, and fibrinogen levels were identified as significant prognostic factors for CCHF mortality.
  • Critically low platelet counts (<20 x 10^9 cells/L) and prolonged aPTT (>60 sec) were strongly associated with fatal outcomes.
  • Protein C, protein S, APCR, and antithrombin III levels did not show a significant association with mortality.

Conclusions:

  • Standard coagulopathy tests (platelet count, PT, aPTT, INR, fibrinogen) are sufficient for monitoring CCHF progression.
  • Certain markers like Protein S, Protein C, APCR, and D-dimer are not reliable predictors of mortality in CCHF.
  • The study highlights the prognostic value of basic coagulation parameters in CCHF management.
Abstract

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