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Imiquimod cream 5% for the treatment of arsenic-induced cutaneous neoplasms
Cheryl Lundeberg Lonergan1, Elizabeth Kaufman McNamara, Kelly M Cordoro
1Department of Dermatology, University of Virginia Health System, Charlottesville, USA. drlonergan@aadermatology.com
Abstract:
Long-term exposure to arsenic has been linked to the development of numerous cutaneous neoplasms including arsenical keratoses, basal cell carcinomas (BCCs), and squamous cell carcinomas (SCCs). We report a patient with a remote history of psoriasis treated with arsenic who subsequently developed more than 40 nonmelanoma skin cancers as well as arsenical keratoses. This patient had a remarkable response to imiquimod cream 5% applied once daily to affected areas for 6 weeks with complete resolution of all cutaneous neoplasms and no evidence of recurrence in more than 3 years of clinical surveillance.
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