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Updated: Jun 12, 2026

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
Published on: September 12, 2019
[Use of immunomodulators in the therapy of chronic hepatitis C: improving standard approach]
Abstract:
Results of a comparative study of the standard and an improved (triple) antiviral therapy in a group of 86 patients with chronic viral hepatitis C (1b genotype) with a period of infection up to five years are presented. The standard therapy consisted in the administration of concentrated alpha-interferon (Interal, Russia) and synthetic nucleozide ribavirin, while the improved (triple) therapy additionally included the administration of the interferon inducer cycloferon. The effectiveness of treatment using the improved scheme increased by 8.8%, the number of adverse drug reactions decreased more than three times, and morphological improvement was observed in 69.4-87.8% of patients. Modification of the standard treatment of hepatitis C improves the quality of life of hepatitis C patients.
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