Related Experiment Video
Updated: Jun 12, 2026
07:37
Translational Orthotopic Models of Glioblastoma Multiforme
Published on: February 17, 2023
Nogo-A expression in oligodendroglial tumors
Tae-Young Jung1, Shin Jung, Kyung-Hwa Lee
1Department of Neurosurgery, Chonnam National University Hwasun Hospital & Medical School, Gwangju, South Korea.
Summary
Nogo-A protein shows high expression in oligodendroglial tumors, correlating with Olig-2. While Nogo-A aids in detecting these tumors, it is not a definitive specific marker.
Area of Science:
- Neuro-oncology
- Molecular pathology
- Immunohistochemistry
Background:
- Nogo-A, a reticulon protein, is found in myelin sheaths of oligodendrocytes.
- Understanding Nogo-A expression is crucial for glioma characterization.
Purpose of the Study:
- To investigate Nogo-A expression patterns in human gliomas.
- To evaluate Nogo-A as a potential diagnostic marker for oligodendroglial tumors.
- To compare Nogo-A expression with Olig-2, a known oligodendroglioma marker.
Main Methods:
- Immunohistochemistry and immunofluorescent staining on 58 astrocytic and oligodendroglial tumors.
- Western blot analysis to confirm protein overexpression in 53 tumors.
- Comparison of Nogo-A expression with Olig-2 and other glial markers (MAP-2, GFAP).
Main Results:
- Nogo-A and Olig-2 showed specificity in distinguishing oligodendroglial from astrocytic tumors (P=0.001).
- Nogo-A staining levels strongly correlated with Olig-2 expression (P=0.001).
- Nogo-A demonstrated 86.9% sensitivity and 57.1% specificity for oligodendroglial tumors.
- Western blot confirmed predominant Nogo-A expression in oligodendroglioma (85.7%) and anaplastic oligodendroglioma (93.7%) cells.
Conclusions:
- Nogo-A is highly expressed in oligodendroglial tumors, similar to other markers.
- Nogo-A expression overlaps with other oligodendroglial markers but exhibits distinct patterns.
- Nogo-A is a valuable marker for detecting oligodendroglial tumors but lacks definitive specificity.
Related Concept Videos
01:31Nervous Tissue: Glial Cells
Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial cells that interact...
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial cells that interact...
01:04Glial Cells
Overview
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
01:25Nervous Tissue: Myelin
The myelin sheath is a multilayered lipid and protein covering that insulates the axon of a neuron, enhancing the speed of nerve impulse conduction. Axons without this sheath are referred to as unmyelinated. Two types of neuroglia, Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS) are responsible for producing myelin sheaths.
Schwann cells begin to form myelin sheaths around axons during fetal development. They wrap around a small...
Schwann cells begin to form myelin sheaths around axons during fetal development. They wrap around a small...