Related Experiment Video
Updated: Jun 12, 2026

Application of Robot-assisted Pancreaticobiliary Junction Resection in Benign Duodenal Tumors
Published on: December 20, 2024
Gallbladder perforation associated with carcinoma of the duodenal papilla: a case report
Akihiro Hosaka1, Mikiko Nagayoshi, Katsuyoshi Sugizaki
1Department of Surgery, Ome Municipal General Hospital, 16-5, Higashi Ome 4-chome, Ome-shi, Tokyo, 198-0042, Japan. hosaka-a@umin.ac.jp
Background:
Gallbladder perforation is a rare clinical condition, which mostly occurs following acute cholecystitis associated with cholelithiasis. A tumor of the ampulla of Vater causes gradually progressive symptoms, and is rarely associated with perforation of the gallbladder.
Case Presentation:
A 56-year-old man with carcinoma of the ampulla of Vater presented with spontaneous gallbladder perforation and localized bile peritonitis. He complained of right upper abdominal pain, and laparotomy revealed perforation of the gallbladder with no gallstones. Postoperative upper gastrointestinal endoscopy demonstrated a slightly enlarged duodenal papilla, and biopsy revealed adenocarcinoma of the ampulla. Pylorus-preserving pancreaticoduodenectomy was performed subsequently.
Conclusion:
Ampullary carcinoma can be associated with gallbladder perforation and present with acute manifestations. Immediate surgical treatment is required for this condition.
Related Concept Videos
Esophageal Perforation-I: Introduction
The location of esophageal perforation can vary, occurring anywhere along the esophagus.
Cholecystitis
Peptic Ulcer Disease III: Clinical Manifestations and Complications
Esophageal Perforation-II: Clinical Manifestations and Management
Clinical Manifestations:
Appendicitis
Endoscopic Procedures V: ERCP
Patient...