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Updated: Jun 12, 2026

Measurement of Tactile Allodynia in a Murine Model of Bacterial Prostatitis
06:46

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Published on: January 16, 2013

Nanobacteria: a possible etiology for type III prostatitis.

Xuecheng Shen1, Aimin Ming, Xin Li

  • 1Urological Research Institute of PLA, Southwest Hospital, Third Military Medical University, Chongqing, People's Republic of China.

The Journal of Urology
|May 22, 2010
PubMed
Summary

Nanobacteria infection in rat prostates caused inflammation and microcalculus formation, suggesting a role in type III prostatitis development. This study highlights nanobacteria as a potential etiological factor in urological disease.

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Area of Science:

  • Urology
  • Microbiology
  • Pathology

Background:

  • Nanobacteria are implicated in urological diseases.
  • Understanding their role in prostatitis is crucial.

Purpose of the Study:

  • To investigate pathological changes in nanobacteria-infected rat prostates.
  • To explore the etiological relationship between nanobacteria and type III prostatitis.

Main Methods:

  • Adult male Sprague-Dawley rats were randomized into control and model groups.
  • Prostate infection models were created via transurethral nanobacteria suspension infusion.
  • Pathology, cytokine levels (IL-1β, TNF-α), and nanobacteria presence were assessed at 1, 2, 4, and 8 weeks.

Main Results:

  • Nanobacteria-infected rat prostates showed acute and chronic inflammation.
  • Microcalculus formation was observed in 70% of infected rats by 8 weeks.
  • Elevated levels of IL-1β and TNF-α were detected in infected prostates, peaking at 2 weeks.

Conclusions:

  • Nanobacteria infection induces prostatitis-like pathological changes in rats.
  • Nanobacteria are identified as a potential etiological factor for type III prostatitis.