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COMT and anxiety and cognition in children with chromosome 22q11.2 deletion syndrome
Vandana Shashi1, Timothy D Howard, Matcheri S Keshavan
1Duke University Medical Center, Division of Medical Genetics, Department of Pediatrics, Durham, North Carolina 27710, USA. vandana.shashi@duke.edu
Abstract:
The COMT gene is thought to contribute to the cognitive/psychiatric phenotypes in 22q11.2 deletion syndrome. We measured these manifestations against the Val/Met alleles of the COMT gene, in 40 nonpsychotic 22q11DS children. The Val allele was associated with poor IQ, processing speed, executive function and a higher frequency of anxiety disorders, underscoring the importance of the COMT gene in the childhood psychopathology in 22q11DS.
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