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Related Experiment Video

Updated: Jun 12, 2026

Quasistatic Mechanical Testing for Computer-Aided Design and Manufacturing Occlusal Veneers Cemented to Milled Dentin Analog Material
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A novel experimental design model for increasing occlusal vertical dimension.

Yan Li1, Zhiguang Zhang, Shuyi Wu

  • 1Department of Prosthodontics, Hospital of Stomatology, Guanghua College of Stomatology, Sun Yat-sen University, Guangzhou, China.

The Journal of Craniofacial Surgery
|May 22, 2010
PubMed
Summary

A new rat model for increasing occlusal vertical dimension (iOVD) was successfully created using prosthodontic techniques. This model allows for studying the effects of altered bite height on dental and temporomandibular joint tissues.

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Area of Science:

  • Biomedical Engineering
  • Dental Research
  • Animal Modeling

Background:

  • Altering occlusal vertical dimension (OVD) is relevant to temporomandibular disorders (TMD).
  • Establishing reliable animal models is crucial for investigating OVD-related changes.
  • Previous models may lack the precision to control OVD changes.

Purpose of the Study:

  • To develop and validate a rat model for studying increasing occlusal vertical dimension (iOVD).
  • To assess the effects of iOVD on dental and temporomandibular joint (TMJ) tissues.
  • To confirm the reliability of a prosthodontic approach for creating iOVD.

Main Methods:

  • Adult Wistar rats were fitted with a maxillary dental splint to increase OVD (iOVD group).
  • Control rats did not receive the splint.

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  • Radiographs, body weight measurements, and histologic analyses of teeth and TMJs were performed at various time points.

    • Main Results:

    • The iOVD rat model was successfully established using prosthodontic techniques.
    • No significant differences in body weight were observed between groups.
    • Histologic analysis revealed remodeling of periodontal tissue and condylar cartilage in the iOVD group, without asymmetric dental abrasions.

    Conclusions:

    • A reproducible rat model for iOVD can be created using prosthodontic methods.
    • This model allows for balanced bilateral occlusal height adjustments.
    • The iOVD model demonstrates tissue remodeling, providing a basis for further TMD research.