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Related Experiment Videos

Antigen processing and presentation: modelling with Leishmania.

P M Kaye1, A J Curry, G J Bancroft

  • 1Dept. of Medical Parasitology, London School of Hygiene and Tropical Medicine, U.K.

Behring Institute Mitteilungen
|February 1, 1991
PubMed
Summary
This summary is machine-generated.

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Antigen-presenting cells (APCs) process foreign antigens for T-cell recognition. Chronic Leishmania infection impairs APC function, leading to T-cell unresponsiveness due to reduced costimulator expression.

Area of Science:

  • Immunology
  • Parasitology
  • Cell Biology

Background:

  • Antigen-presenting cells (APCs) process foreign antigens for T-cell receptor (TCR) recognition via MHC molecules.
  • Leishmania donovani infection involves uptake into phagolysosomes, with subsequent MHC class II upregulation during infection.

Purpose of the Study:

  • To investigate the interaction sites of MHC-antigen (Ag) following Leishmania donovani uptake.
  • To understand the role of NK cells and APC function during chronic infection.

Main Methods:

  • Functional assays and immuno-gold labeling studies.
  • Studies using severe combined immunodeficient (scid) mice.

Main Results:

  • Upregulation of MHC class II occurs during Leishmania infection in vivo.

Related Experiment Videos

  • NK cells contribute minimally to the process.
  • APC function diminishes during chronic infection despite high MHC class II levels.

    • Conclusions:

    • A lack of coordinate costimulator expression may lead to T-cell unresponsiveness late in chronic infection.
    • This unresponsiveness is proposed to be induced by impaired APC function.