Related Experiment Video
Updated: Jun 12, 2026

Introduction to Solid Supported Membrane Based Electrophysiology
Published on: May 11, 2013
The Role of Plasmalemmal-Cortical Anchoring on the Stability of Transmembrane Electropores
S M Kennedy1, Z Ji, N B Rockweiler
1Department of Electrical and Computer Engineering, University of Wisconsin, Madison Madison, WI, 53706, USA.
Abstract:
The structure of eukaryotic cells is maintained by a network of filamentous actin anchored subjacently to the plasma membrane. This structure is referred to as the actin cortex. We present a locally constrained surface tension model for electroporation in order to address the influence of plasmalemmal-cortical anchoring on electropore dynamics. This model predicts that stable electropores are possible under certain conditions. The existence of stable electropores has been suggested in several experimental studies. The electropore radius at which stability is achieved is a function of the characteristic radii of locally constrained regions about the plasma membrane. This model opens the possibility of using actin-modifying compounds to physically manipulate cortical density, thereby manipulating electroporation dynamics. It also underscores the need to improve electroporation models further by incorporating the influence of trans-electropore ionic and aqueous flow, cortical flexibility, transmembrane protein mobility, and active cellular wound healing mechanisms.
More Related Videos
08:09A Micro-agar Salt Bridge Electrode for Analyzing the Proton Turnover Rate of Recombinant Membrane Proteins
Published on: January 7, 2019
09:54Multifunctional, Micropipette-based Method for Incorporation And Stimulation of Bacterial Mechanosensitive Ion Channels in Droplet Interface Bilayers
Published on: November 19, 2015
Related Concept Videos
Cell Motility through Blebbing
Blebbing Through the Matrix
In multicellular...
Anchoring Junctions
Enlargement of the Plasma Membrane
Membrane Asymmetry Regulating Transporters
Flippase
Eukaryotic flippases are type-IV P-type ATPases or P4-ATPases belonging to P-type ATPase family proteins that are membrane-bound pumps involved in the ATP-mediated transport of ions and molecules across the membrane. Flippases flip specific phospholipids from the outer to the inner leaflet of a membrane. All P4-ATPases have one...
Protein Diffusion in the Membrane
Resting Potential Decay
At rest, the K+ is the main ion that moves across the membrane through...