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Development and evaluation of controlled release ibuprofen matrix tablets by direct compression technique
Nisha Patel1, Parshotam Madan, Senshang Lin
1College of Pharmacy and Allied Health Professions, St John's University, Queens, New York, USA.
Pharmaceutical Development and Technology
|May 25, 2010
Summary
Controlled release ibuprofen matrix tablets were developed using direct compression. Formulation variables, like Eudragit concentration, controlled ibuprofen release rates, primarily via diffusion initially.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
- Materials Science
Background:
- Developing effective controlled-release drug formulations is crucial for improving therapeutic outcomes and patient compliance.
- Matrix tablet systems offer a versatile approach for sustained drug release.
- Ibuprofen, a common non-steroidal anti-inflammatory drug, requires optimized delivery for prolonged action.
Purpose of the Study:
- To develop and evaluate controlled-release ibuprofen matrix tablets.
- To investigate the impact of Eudragit RSPO concentration on ibuprofen release kinetics.
- To determine the drug release mechanism from the fabricated matrix tablets.
Main Methods:
- Matrix tablets (400 mg) were prepared by direct compression of ibuprofen (100 mg) with Eudragit RSPO and Avicel PH 101.
- Eudragit RSPO concentration was varied from 10% to 50% in 5% increments.
- Ibuprofen release profiles were analyzed using established kinetic models (e.g., diffusion, erosion).
Main Results:
- Ibuprofen release rate was significantly influenced by Eudragit RSPO concentration.
- Tablets with 50% Eudragit RSPO released approximately 40% of ibuprofen in 4 hours, while those with 10% released 100%.
- The primary release mechanism was polymer diffusion-controlled for the initial 4 hours, followed by complex mechanisms due to matrix erosion.
Conclusions:
- Controlled-release ibuprofen matrix tablets with tunable release rates can be successfully fabricated using direct compression.
- Formulation variables, particularly polymer concentration, are key to achieving desired drug release profiles.
- The study demonstrates the feasibility of producing effective ibuprofen matrix tablets for sustained drug delivery.
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