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Paroxysmal disorders in infancy and their risk factors in a population-based cohort: the Generation R Study
Annemarie M Visser1, Vincent W V Jaddoe, Lidia R Arends
1The Generation R Study Group, Department of Biostatistics and Institute of Psychology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Developmental Medicine and Child Neurology
|May 25, 2010
Summary
Paroxysmal disorders are common in infants, with preterm birth and low Apgar scores being significant predictors. Maternal smoking during pregnancy also increased the risk of febrile seizures in newborns.
Area of Science:
- Pediatrics
- Neonatal Medicine
- Neurology
Background:
- Paroxysmal disorders are common in infancy, encompassing both epileptic and non-epileptic events.
- Identifying predictive factors for these disorders is crucial for early intervention and management.
Purpose of the Study:
- To determine the incidence of paroxysmal epileptic and non-epileptic disorders in the first year of life.
- To investigate prenatal and perinatal factors associated with these disorders in a population-based cohort.
Main Methods:
- Prospective, population-based cohort study (Generation R Study) from early fetal life.
- Questionnaires collected data on paroxysmal events at 2, 6, and 12 months of age.
- Prenatal and perinatal determinants were assessed through measurements and questionnaires.
Main Results:
- An incidence of 8.9% for paroxysmal disorders was observed in the first year of life.
- Preterm birth and low Apgar score at 1 minute were significantly associated with paroxysmal disorders.
- Continued maternal smoking and preterm birth were linked to an increased incidence of febrile seizures.
Conclusions:
- Paroxysmal disorders are frequent in infancy, with preterm birth and low Apgar scores as key associated factors.
- Epileptic seizures constitute a small proportion of infantile paroxysmal events.
- Maternal smoking during pregnancy is associated with a higher incidence of febrile seizures, warranting further investigation.
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