Related Experiment Video

Updated: Jun 12, 2026

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

Paroxysmal disorders in infancy and their risk factors in a population-based cohort: the Generation R Study

Annemarie M Visser1, Vincent W V Jaddoe, Lidia R Arends

  • 1The Generation R Study Group, Department of Biostatistics and Institute of Psychology, Erasmus University Medical Center, Rotterdam, the Netherlands.

Developmental Medicine and Child Neurology
|May 25, 2010
PubMed

Insights

Paroxysmal disorders are common in infants, with preterm birth and low Apgar scores being significant predictors. Maternal smoking during pregnancy also increased the risk of febrile seizures in newborns.

Area of Science:

  • Pediatrics
  • Neonatal Medicine
  • Neurology

Background:

  • Paroxysmal disorders are common in infancy, encompassing both epileptic and non-epileptic events.
  • Identifying predictive factors for these disorders is crucial for early intervention and management.

Purpose of the Study:

  • To determine the incidence of paroxysmal epileptic and non-epileptic disorders in the first year of life.
  • To investigate prenatal and perinatal factors associated with these disorders in a population-based cohort.

Main Methods:

  • Prospective, population-based cohort study (Generation R Study) from early fetal life.
  • Questionnaires collected data on paroxysmal events at 2, 6, and 12 months of age.
  • Prenatal and perinatal determinants were assessed through measurements and questionnaires.

Main Results:

  • An incidence of 8.9% for paroxysmal disorders was observed in the first year of life.
  • Preterm birth and low Apgar score at 1 minute were significantly associated with paroxysmal disorders.
  • Continued maternal smoking and preterm birth were linked to an increased incidence of febrile seizures.

Conclusions:

  • Paroxysmal disorders are frequent in infancy, with preterm birth and low Apgar scores as key associated factors.
  • Epileptic seizures constitute a small proportion of infantile paroxysmal events.
  • Maternal smoking during pregnancy is associated with a higher incidence of febrile seizures, warranting further investigation.
Abstract

More Related Videos

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia13:08

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

Published on: December 2, 2015

Related Concept Videos

Prevalence and Incidence01:08

Prevalence and Incidence

In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health condition at a...
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings.
Oppositional Defiant Disorder01:30

Oppositional Defiant Disorder

A persistent pattern of angry or irritable mood, defiant behavior, or vindictiveness characterizes Oppositional Defiant Disorder (ODD). Symptoms must occur over at least six months, involve interactions with individuals beyond siblings, and meet specific diagnostic criteria to be clinically significant. The disorder affects emotional regulation, social interactions, and behavior, often manifesting early in life and influencing long-term development and functioning.
Diagnostic Criteria and...
Pedigree Analysis01:35

Pedigree Analysis

Overview
Factors Affecting Illness01:18

Factors Affecting Illness

When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness, disability,...