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Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
Published on: December 14, 2020
Can acid (pH) refluxes predict multichannel intraluminal impedance refluxes? A correlation study
1Division of Gastroenterology, Children's Medical Center, Medical College of Georgia, Augusta, Georgia 309012, USA. smisra@mail.mcg.edu
Journal of Gastroenterology and Hepatology
|May 25, 2010
Summary
In children without acid suppression, pH probe studies adequately detect acid and volume refluxes, potentially replacing multichannel intraluminal impedance (MII)-pH studies for gastroesophageal reflux diagnosis.
Area of Science:
- Gastroenterology
- Pediatric Medicine
- Diagnostic Technology
Background:
- Gastroesophageal reflux (GER) is common in children.
- Differentiating acid vs. non-acid reflux requires advanced diagnostics.
- Multichannel intraluminal impedance (MII)-pH monitoring is a key diagnostic tool.
Purpose of the Study:
- To determine if acid (pH) refluxes predict multichannel intraluminal impedance (MII) detected refluxes.
- To assess the interchangeability of pH probe-only and MII-pH studies in pediatric GER.
Main Methods:
- Prospective observational cross-sectional study of symptomatic children (<18 years) undergoing MII-pH studies.
- Analysis of clinical data and reflux indices using non-parametric tests, Pearson's rho, and ROC curves.
- Comparison of reflux detection with and without acid suppression medication.
Main Results:
- Correlation between acid and MII reflux indices was significant only in children not on acid suppression.
- No significant difference in acid or MII reflux indices based on acid suppression status.
- MII reflux indices showed good internal correlation, and liquid/mixed refluxes correlated well with proximal migration.
Conclusions:
- pH probe-only studies may adequately assess both acid and volume reflux in children without acid suppression.
- pH probe-only studies could serve as a substitute for MII-pH studies in specific pediatric GER cases.
- Findings support the use of pH probe-only studies for extraesophageal symptoms in non-suppressed patients.
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