Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Herniated Intervertebral Disc l: Introduction01:29

Herniated Intervertebral Disc l: Introduction

Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...
Spinal Nerves: Plexus II01:21

Spinal Nerves: Plexus II

The plexuses of the lower body include the lumbar, sacral, and coccygeal plexuses, which innervate the abdomen, pelvis, legs, and coccygeal region. These plexuses control the transmission of sensory information and coordinate motor functions of the lower body.
The Lumbar Plexus
The lumbar plexus is situated within the lumbar region of the back and is primarily formed by the first four lumbar spinal nerves (L1 to L4). This plexus extends its branches into several nerves, including the...
Spinal Nerves: Anatomy01:23

Spinal Nerves: Anatomy

Spinal nerves are pivotal conduits in the nervous system, bridging the central nervous system (CNS) with the peripheral nervous system (PNS). These nerves enable a complex communication network between the brain, spinal cord, and the rest of the body, facilitating sensory input, motor output, and autonomic functions.
There are 31 bilateral pairs of spinal nerves, each emerging from the spinal cord through the intervertebral foramina—openings between adjacent vertebrae. These nerves are...
Spinal Nerves: Plexus I01:22

Spinal Nerves: Plexus I

Nerve plexuses are networks of interlacing nerves that serve as communication hubs to distribute and organize nerve action across various body regions. The nerve plexuses are organized into the cervical plexus located in the neck region, brachial plexus in the shoulder area, lumbar plexus found in the lower back, sacral plexus situated in the pelvis, and coccygeal plexus located in the coccygeal region.
The Cervical Plexus
The cervical plexus, formed by the anterior rami of the first four...
Degenerative Disc Disease ll: Pathophysiology01:23

Degenerative Disc Disease ll: Pathophysiology

The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pain prevalence and intensity in advanced pancreatic cancer: a nationwide cohort study.

Pain·2026
Same author

Accuracy in spinal level determination, including transitional vertebrae: an ASReview supported systematic review.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2026
Same author

Prognostic Value of Selective Nerve Root Blocks Prior to Pulsed Radiofrequency in the Treatment of Patients With Chronic Radicular Pain: A Systematic Review.

Pain practice : the official journal of World Institute of Pain·2026
Same author

Clinical Practice Variations in Interventional Treatment of Chronic Lumbosacral Radicular Pain Among Registered Dutch Pain Specialists: A National Survey.

Pain practice : the official journal of World Institute of Pain·2026
Same author

CMS Proposed Restrictions on Peripheral Nerve Blocks and Procedures for Chronic Pain: Clinical, Ethical, and Policy Implications for Millions of Americans.

Pain medicine (Malden, Mass.)·2026
Same author

Transcriptomic Analysis of the Impact of the <i>tet</i>(X4) Gene on the Growth Characteristics and Antibiotic Resistance Phenotypes of <i>Escherichia coli</i> Isolated from Musk Deer.

Animals : an open access journal from MDPI·2025

Related Experiment Video

Updated: Jun 12, 2026

Laminotomy for Lumbar Dorsal Root Ganglion Access and Injection in Swine
09:00

Laminotomy for Lumbar Dorsal Root Ganglion Access and Injection in Swine

Published on: October 10, 2017

11. Lumbosacral radicular pain.

Koen Van Boxem1, Jianguo Cheng, Jacob Patijn

  • 1Department of Anesthesiology and Pain Management, Maastricht University Medical Centre, Maastricht, The Netherlands. koen.vb@telenet.be

Pain Practice : the Official Journal of World Institute of Pain
|May 25, 2010
PubMed
Summary

Lumbosacral radicular pain, a common neuropathic condition, affects over 25% of the population. Diagnosis involves clinical tests and imaging, with treatments ranging from conservative care to advanced interventions like spinal cord stimulation for severe cases.

Related Experiment Videos

Last Updated: Jun 12, 2026

Laminotomy for Lumbar Dorsal Root Ganglion Access and Injection in Swine
09:00

Laminotomy for Lumbar Dorsal Root Ganglion Access and Injection in Swine

Published on: October 10, 2017

Area of Science:

  • Neurology
  • Pain Medicine
  • Neurosurgery

Background:

  • Lumbosacral radicular pain involves radiating pain in lumbar/sacral dermatomes, potentially with functional deficits.
  • It is the most prevalent form of neuropathic pain, with an annual prevalence of 9.9%–25% in the general population.
  • Diagnosis relies on patient history, clinical examination (e.g., straight-leg raising test), and potentially advanced imaging.

Purpose of the Study:

  • To outline the diagnostic approaches for lumbosacral radicular pain.
  • To review current treatment strategies for various stages of the condition.
  • To highlight advanced interventions for refractory cases and failed back surgery syndrome.

Main Methods:

  • Review of clinical diagnostic criteria and investigations.
  • Analysis of evidence for conservative and pharmacological treatments.
  • Evaluation of interventional procedures including corticosteroid injections, radiofrequency treatment, adhesiolysis, epiduroscopy, and spinal cord stimulation.

Main Results:

  • Medical imaging, particularly MRI, is crucial for excluding serious pathologies and confirming affected levels in chronic cases.
  • Selective diagnostic blocks aid in pinpointing the pain source.
  • Transforaminal corticosteroid administration is recommended for subacute pain below L3 from contained herniation when conservative treatment fails.
  • (Pulsed) radiofrequency treatment near the dorsal root ganglion is an option for chronic pain.
  • Adhesiolysis and epiduroscopy may be considered for refractory pain.
  • Spinal cord stimulation is recommended for therapy-resistant radicular pain in Failed Back Surgery Syndrome patients.

Conclusions:

  • Accurate diagnosis of lumbosacral radicular pain requires a combination of clinical assessment and diagnostic tools.
  • Treatment selection depends on pain chronicity, severity, and underlying pathology.
  • Advanced interventions like spinal cord stimulation offer effective solutions for complex and refractory cases, necessitating specialized centers.