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09:03
The Perinatal Asphyxiated Lamb Model: A Model for Newborn Resuscitation
Published on: August 15, 2018
Peripheral oxygenation and management in the perinatal period
1University of Liverpool Neonatal Unit, Liverpool Women's Hospital, Liverpool L8 7SS, UK. a.m.weindling@liv.ac.uk
Seminars in Fetal & Neonatal Medicine
|May 25, 2010
Summary
Adequate oxygen delivery to tissues relies on complex circulatory controls, blood properties, and oxygen transport dynamics. The body typically consumes 15-33% of transported oxygen, a crucial factor in maintaining tissue oxygenation.
Area of Science:
- Physiology
- Cardiovascular Science
Background:
- Oxygen delivery to peripheral tissues is a complex physiological process.
- It involves intricate regulation of microcirculation, blood flow, and oxygen transport factors.
Purpose of the Study:
- To elucidate the multifaceted mechanisms governing adequate oxygen supply to tissues.
- To explore the relationship between oxygen delivery, consumption, and extraction.
Main Methods:
- Review of physiological mechanisms controlling microcirculation and peripheral blood flow.
- Analysis of factors influencing the oxygen dissociation curve, including hemoglobin types.
- Examination of blood gases and viscosity impacts on oxygen transport.
Main Results:
- Systemic blood pressure has minimal impact on oxygen delivery in non-shocked states.
- Adequate oxygen delivery (DO(2)) is intrinsically linked to variable oxygen consumption (VO(2)).
- Fractional oxygen extraction (FOE = VO(2)/DO(2)) quantifies this balance, ranging from 0.15-0.33 (15-33%) for the whole body.
Conclusions:
- Oxygen delivery is regulated by a complex interplay of circulatory and blood-related factors.
- Fractional oxygen extraction is a key indicator of the balance between oxygen supply and demand.
- Understanding these mechanisms is vital for comprehending tissue oxygenation and metabolic homeostasis.
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