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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Liver Regeneration01:24

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

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Related Experiment Video

Updated: Jun 12, 2026

Robust Generation of Hepatocyte-like Cells from Human Embryonic Stem Cell Populations
05:49

Robust Generation of Hepatocyte-like Cells from Human Embryonic Stem Cell Populations

Published on: October 26, 2011

Recent advances in liver stem cell therapy.

Tatiana Kisseleva, Elia Gigante, David A Brenner

    Current Opinion in Gastroenterology
    |May 25, 2010
    PubMed
    Summary
    This summary is machine-generated.

    Liver cell transplantation shows promise for treating liver cirrhosis, using cells like hepatocytes and induced pluripotent stem (iPS) cells to regenerate damaged livers. This experimental approach offers a potential alternative to traditional liver transplantation.

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    Application of Live Mitochondria Staining in Cell-Sorting to Purify Hepatocytes Derived from Human Induced Pluripotent Stem Cells

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    Robust Generation of Hepatocyte-like Cells from Human Embryonic Stem Cell Populations
    05:49

    Robust Generation of Hepatocyte-like Cells from Human Embryonic Stem Cell Populations

    Published on: October 26, 2011

    Isolation of CD133+ Liver Stem Cells for Clonal Expansion
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    Published on: October 10, 2011

    Application of Live Mitochondria Staining in Cell-Sorting to Purify Hepatocytes Derived from Human Induced Pluripotent Stem Cells
    08:51

    Application of Live Mitochondria Staining in Cell-Sorting to Purify Hepatocytes Derived from Human Induced Pluripotent Stem Cells

    Published on: December 1, 2023

    Area of Science:

    • Hepatology and regenerative medicine.
    • Cellular biology and transplantation.
    • Gastroenterology and liver disease research.

    Background:

    • Liver cirrhosis necessitates liver transplantation, the sole definitive treatment for end-stage disease.
    • Intrahepatic liver cells, including hepatocytes, oval cells, stem cells, and induced pluripotent stem (iPS) cells, offer potential for liver repopulation.
    • Current research explores these cell types for therapeutic liver regeneration.

    Discussion:

    • Liver cell transplantation is an experimental therapy successfully employed in clinical trials for acute liver failure and chronic liver disease.
    • Oval cells, identified as bipotential intrahepatic progenitor cells, demonstrate capacity for proliferation and differentiation into hepatocytes and cholangiocytes.
    • Induced pluripotent stem (iPS) cells can be differentiated into hepatocytes in vitro, offering a patient-specific therapeutic avenue.

    Key Insights:

    • Oval cells actively participate in liver regeneration by differentiating into hepatocytes and cholangiocytes.
    • iPS cells derived from patients can be cultured and differentiated into functional liver cells.
    • Diverse hepatic cell populations are being investigated for their potential in advancing liver cell transplantation therapies.

    Outlook:

    • Future research will focus on optimizing conditions for expanding and differentiating somatic cells into mature, functional liver cells.
    • Developing standardized protocols for liver cell transplantation is crucial for clinical application.
    • Advancing liver cell transplantation holds significant potential for managing and treating hepatic cirrhosis.