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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying DNA...
Heterochromatin02:38

Heterochromatin

The extent of chromatin compaction can be studied by staining chromatin using specific DNA binding dyes. Under the microscope, the dense-compacted regions that take up more dye are called heterochromatin. Heterochromatin is further classified into two forms – constitutive heterochromatin and facultative heterochromatin.
Constitutive heterochromatin: It is a highly compact region of chromatin that is mostly concentrated in the centromere and telomere. Unlike euchromatin, the amino acid at 9th...
Heterochromatin02:38

Heterochromatin

The extent of chromatin compaction can be studied by staining chromatin using specific DNA binding dyes. Under the microscope, the dense-compacted regions that take up more dye are called heterochromatin. Heterochromatin is further classified into two forms – constitutive heterochromatin and facultative heterochromatin.
Constitutive heterochromatin: It is a highly compact region of chromatin that is mostly concentrated in the centromere and telomere. Unlike euchromatin, the amino acid at 9th...

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Related Experiment Video

Updated: Jun 12, 2026

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
09:42

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

Published on: September 7, 2017

Cortical DNA methylation maintains remote memory.

Courtney A Miller1, Cristin F Gavin, Jason A White

  • 1Department of Neurobiology and Evelyn F. McKnight Brain Institute, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA. cmiller@scripps.edu

Nature Neuroscience
|May 25, 2010
PubMed
Summary
This summary is machine-generated.

Long-term memory in the brain may be preserved by DNA methylation, a process that maintains cellular memory. Inhibiting this methylation mechanism disrupted remote memories in rats, suggesting its crucial role in memory persistence.

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Last Updated: Jun 12, 2026

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
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Published on: September 7, 2017

Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 (Kir4.1)
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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Epigenetics

Background:

  • Behavioral memory persistence implies a self-perpetuating molecular signal.
  • DNA methylation is a known mechanism for maintaining cellular memory during development.

Purpose of the Study:

  • To investigate the role of DNA methylation in preserving long-lasting memories in the adult brain.
  • To determine if gene-specific cortical hypermethylation is induced by learning and if its inhibition affects memory recall.

Main Methods:

  • Induction of associative learning in rats.
  • Assessment of gene-specific cortical DNA methylation patterns post-learning.
  • Pharmacologic inhibition of DNA methylation one month after learning.
  • Evaluation of remote memory recall after methylation inhibition.

Main Results:

  • A single, hippocampus-dependent associative learning experience induced persistent, gene-specific cortical hypermethylation.
  • Pharmacologic inhibition of methylation one month after learning significantly disrupted remote memory recall.

Conclusions:

  • The adult brain utilizes DNA methylation to preserve long-lasting memories.
  • Gene-specific cortical hypermethylation is a potential epigenetic mechanism underlying memory consolidation and persistence.