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Related Experiment Video

Updated: Jun 12, 2026

Quantifying the Antifungal Activity of Peptides Against Candida albicans

Quantifying the Antifungal Activity of Peptides Against Candida albicans

Published on: January 13, 2023

Peptide-based Antifungal Therapies against Emerging Infections.

A Matejuk¹, Q Leng, M D Begum

¹Department of Pathology, University of Maryland Baltimore, MSTF Building, 10 South Pine Street, Baltimore, MD 21201, USA.

Drugs of the Future

|May 25, 2010

Summary

Antifungal peptides offer a promising new strategy against drug-resistant fungal infections, especially in immunocompromised patients. Research is advancing peptide-based therapies for challenging mycotic infections.

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Production and Testing of Antimicrobial Peptides and Their Mimics

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Last Updated: Jun 12, 2026

Quantifying the Antifungal Activity of Peptides Against Candida albicans

Quantifying the Antifungal Activity of Peptides Against Candida albicans

Published on: January 13, 2023

Production and Testing of Antimicrobial Peptides and Their Mimics

Production and Testing of Antimicrobial Peptides and Their Mimics

Published on: April 10, 2026

Area of Science:

Microbiology
Pharmacology
Biotechnology

Background:

Acquired drug resistance in mycotic infections presents a growing global health challenge.
Opportunistic fungal infections pose significant risks to immunocompromised individuals, including those with AIDS, cancer, and transplant recipients.
Increasing mortality rates from invasive mycosis necessitate the development of novel antifungal agents due to widespread antibiotic resistance.

Purpose of the Study:

To review recent advancements in peptide therapy for opportunistic fungal infections.
To highlight the potential of antifungal peptides as novel therapeutic agents.
To discuss the mechanisms and therapeutic utility of plant and animal-derived peptides.

Main Methods:

Review of current scientific literature on antifungal peptides.
Analysis of recent progress in protein engineering and solid-phase synthesis techniques.
Evaluation of the efficacy and toxicity profiles of selected antifungal peptides.

Main Results:

Antifungal peptides, found in plants and animals, show significant potential as therapeutic agents.
Advances in synthesis and engineering enable the development of peptides with specific targets or multifunctional actions.
Selected peptides demonstrate efficient antifungal activity with acceptable toxicity profiles.

Conclusions:

Peptide therapy represents a promising avenue for combating drug-resistant fungal infections.
Further research and development in antifungal peptides are crucial for addressing therapeutic challenges in immunocompromised populations.
The utility of engineered peptides offers hope for improved treatment outcomes in invasive mycosis.