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Updated: Jun 12, 2026

Fat Preference: A Novel Model of Eating Behavior in Rats
Published on: June 27, 2014
Estrogens inhibit food intake in CCK-1 receptor-deficient rats
Shuichi Okamoto1, Maki Shimizu, Akiko Mizuno
1Department of Integrative Physiology, Faculty of Medical Sciences, University of Fukui, Eiheiji-cho, Matsuoka, Fukui, 910-1193, Japan.
Abstract:
In human and many other animals, estrogens inhibit food intake and increases spontaneous activity. Previous studies hypothesized that the anorexigenic effect of estrogens is mediated by the cholecystokinin (CCK)-induced satiety effect. In the present study, we investigated whether estrogens-induced anorexigenic and hyper-active effects are present in Otsuka-Long-Evans-Tokushima-Fatty (OLETF) rat, which is deficient in the CCK1 receptor. In OLETF rats with a regular 4-day estrous cycle, food intake decreased and spontaneous activity increased significantly more during estrus than diestrus as compared to control Long-Evans-Tokushima-Otsuka (LETO) rats. Subcutaneous injection of estradiol benzoate into ovariectomized OLETF rats significantly decreased feeding and increased spontaneous activity to the same extent as in LETO rats. These results suggest that the anorexigenic and hyper-active effects of estrogen can be mediated via pathways other than CCK-CCK1 receptor signaling pathway in CCK1 receptor-deficient rats.
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