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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Oral Drug Delivery Systems: Introduction01:23

Oral Drug Delivery Systems: Introduction

Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.

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Related Experiment Video

Updated: Jun 12, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
10:10

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

Cyclodextrins for drug delivery.

A L Laza-Knoerr1, R Gref, P Couvreur

  • 1UMR CNRS 8612, Facult&#x00E9; de Pharmacie, Univ. Paris-Sud, 5 rue JB Cl&#x00E9;ment, 92296 Ch&#x00E2;tenay-Malabry, France.

Journal of Drug Targeting
|May 26, 2010
PubMed
Summary
This summary is machine-generated.

Cyclodextrins (CDs) are versatile supramolecular hosts forming complexes with diverse molecules. This review highlights recent advancements in using cyclodextrins for enhanced drug delivery across various administration routes.

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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
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Area of Science:

  • Supramolecular Chemistry
  • Medicinal Chemistry
  • Materials Science

Background:

  • Cyclodextrins (CDs) are macrocyclic oligosaccharides with a unique cage-like structure.
  • They exhibit molecular recognition and chiral recognition capabilities, forming inclusion complexes with various guest molecules.
  • CDs have been extensively studied for their ability to modify the properties of complexed substances.

Purpose of the Study:

  • To review recent developments in the application of cyclodextrins for drug delivery.
  • To explore the use of cyclodextrin derivatives in enhancing drug solubility and in vivo activity.
  • To cover various routes of administration for cyclodextrin-based drug delivery systems.

Main Methods:

  • Literature review of recent publications on cyclodextrins in drug delivery.
  • Analysis of studies focusing on cyclodextrin derivatives and their complexation with drugs.
  • Examination of research on different administration routes for cyclodextrin-mediated drug delivery.

Main Results:

  • Cyclodextrins are effective supramolecular hosts for a wide range of molecules.
  • CD derivatives significantly enhance the in vivo solubility and activity of various drugs.
  • Recent advancements show promising applications of CDs in diverse drug delivery systems.

Conclusions:

  • Cyclodextrins represent a key supramolecular host family with broad applicability in drug delivery.
  • The ability of CDs to form inclusion complexes is crucial for improving drug performance.
  • Further research into cyclodextrin-based systems holds significant potential for pharmaceutical innovation.