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The cost-effectiveness of pathogen reduction technology as assessed using a multiple risk reduction model
Brian Custer1, Maria Agapova, Rebecca Havlir Martinez
1Blood Systems Research Institute, San Francisco, California 94118, USA. bcuster@bloodsystems.org
Transfusion
|May 26, 2010
Summary
Pathogen reduction technology (PRT) offers potential to enhance blood safety by mitigating transfusion risks. Cost-effectiveness analyses show PRT is a valuable consideration for improving transfusion safety, despite some uncertainties.
Area of Science:
- Transfusion Medicine
- Health Economics
- Infectious Disease Prevention
Background:
- Pathogen reduction technology (PRT) aims to decrease transfusion-associated adverse events.
- The economic impact of PRT is crucial for its adoption in healthcare systems.
Purpose of the Study:
- To evaluate the cost-utility of riboflavin-based pathogen reduction technology (PRT) for labile blood components in Canada.
- To compare PRT against existing blood safety measures for various transfusion-transmitted risks.
Main Methods:
- Decision analytic models were employed to assess cost-effectiveness from a healthcare system perspective.
- Models compared current interventions with whole blood PRT and platelets-and-plasma PRT.
- The analysis included risks such as HIV, HBV, HCV, bacterial contamination, and transfusion reactions.
Main Results:
- Whole blood PRT demonstrated a cost-effectiveness of $1,276,000 per quality-adjusted life-year (QALY).
- Platelets-and-plasma PRT showed a cost-effectiveness of $1,423,000 per QALY.
- These estimates provide a basis for understanding the economic value of PRT.
Conclusions:
- Modeling PRT cost-effectiveness involves necessary assumptions due to transfusion complexity.
- While uncertainties exist for certain risk reductions, PRT modeling informs policy decisions.
- PRT is a significant consideration for enhancing transfusion safety initiatives.
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