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Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
Published on: December 28, 2017
Risk factors for fluconazole-resistant candidemia
José Garnacho-Montero1, Ana Díaz-Martín, Emilio García-Cabrera
1Critical Care and Emergency Department, Intensive Care Unit, Virgen del Rocío University Hospital, Avenida Manuel Siurot s/n, Seville 41013, Spain. jose.garnacho.sspa@juntadeandalucia.es
Antimicrobial Agents and Chemotherapy
|May 26, 2010
Summary
Previous fluconazole exposure is a key risk factor for fluconazole-resistant candidemia. This finding aids in selecting empirical antifungal therapy for invasive Candida infections.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Clinical Microbiology
Background:
- Candidemia poses a significant threat, with varying risk factors for non-albicans Candida and fluconazole-resistant strains.
- Understanding these factors is crucial for effective empirical antifungal treatment selection.
Purpose of the Study:
- To identify independent risk factors for microbiologically proven fluconazole-resistant candidemia.
- To differentiate risk factors for non-albicans Candida or potentially fluconazole-resistant Candida species.
Main Methods:
- Prospective study of adult patients with candidemia.
- Logistic regression analysis to assess risk factors including demographics, comorbidities, and prior antifungal exposure.
- Inclusion of 226 candidemia episodes for analysis.
Main Results:
- Thirty isolates exhibited confirmed fluconazole resistance.
- Independent predictors for fluconazole-resistant candidemia included neutropenia, chronic renal disease, and prior fluconazole exposure.
- Prior fluconazole exposure was not a significant risk factor for non-albicans or potentially fluconazole-resistant Candida species.
Conclusions:
- Prior fluconazole treatment is an independent risk factor specifically for fluconazole-resistant candidemia.
- Findings support targeted empirical antifungal therapy selection based on patient risk factors.
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