Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Inflammation01:38

Inflammation

Overview
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
Allergic Reactions02:06

Allergic Reactions

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Excessive epithelial mechanosensation drives nociceptive innervation and chronic bladder pain via the PIEZO1-SLC7A11-glutamate axis.

Cell·2026
Same author

Dual-adjuvant mucosal vaccine leveraging mast cell and TLR9 agonists for protection against poxvirus infection.

RSC pharmaceutics·2026
Same author

TRPV4-Mast Cell Interactions in Neurogenic Inflammation and Chronic Diseases: A Narrative Review.

International journal of molecular sciences·2026
Same author

Immune mechanisms of congenital Zika syndrome.

Science immunology·2026
Same author

Autophagy-driven MHC-I downregulation enables NK cell-mediated clearance of intracellular uropathogenic <i>E. coli</i> in urinary tract infection.

Animal cells and systems·2025
Same author

Platelet-mediated activation of perivascular mast cells triggers progression of sepsis to septic shock in mice.

Nature communications·2025
Same journal

A guide to CAR T cell therapies: development, current status and future prospects.

Nature reviews. Immunology·2026
Same journal

Macrophages in embryonic development.

Nature reviews. Immunology·2026
Same journal

Glycolytic capacity instructs tumour vasculature and response to immunotherapy.

Nature reviews. Immunology·2026
Same journal

Vaginal NK cells limit epithelial barrier disruption during infection.

Nature reviews. Immunology·2026
Same journal

New insights into progenitor exhausted T cell populations.

Nature reviews. Immunology·2026
Same journal

T cell engagers in autoimmune diseases.

Nature reviews. Immunology·2026
See all related articles

Related Experiment Video

Updated: Jun 12, 2026

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis
16:01

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

Published on: January 26, 2015

Mast cell-orchestrated immunity to pathogens.

Soman N Abraham1, Ashley L St John

  • 1Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA. soman.abraham@duke.edu

Nature Reviews. Immunology
|May 26, 2010
PubMed
Summary
This summary is machine-generated.

Mast cells, beyond allergies, are key immune cells that detect pathogens and initiate protective responses. Harnessing mast cell activators shows promise for developing new vaccines against microbial infections.

More Related Videos

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays
11:31

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays

Published on: July 4, 2018

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
09:07

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Published on: May 27, 2015

Related Experiment Videos

Last Updated: Jun 12, 2026

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis
16:01

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis

Published on: January 26, 2015

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays
11:31

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays

Published on: July 4, 2018

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice
09:07

Analyzing the Functions of Mast Cells In Vivo Using 'Mast Cell Knock-in' Mice

Published on: May 27, 2015

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Mast cells, known for allergic reactions, have recently gained recognition for their crucial role in pathogen recognition and immune response modulation.
  • Their strategic location at the host-environment interface and rapid mediator release make them vital for effective anti-infection immunity.

Purpose of the Study:

  • To explore the multifaceted roles of mast cells in immune responses beyond allergic reactions.
  • To understand how mast cells contribute to host defense against pathogens and their potential in vaccine development.

Main Methods:

  • Review of recent immunological studies investigating mast cell functions.
  • Analysis of mast cell-mediated inflammatory environment alteration and immune cell mobilization.
  • Evaluation of mast cell activators as vaccine adjuvants.

Main Results:

  • Mast cells are critical for optimal immune responses during infection by detecting pathogens and modulating inflammation.
  • They mobilize various immune cells to infection sites and draining lymph nodes.
  • The nature of mast cell responses is influenced by pathogen type, recognition site, and mast cell sensitization.

Conclusions:

  • Mast cells play a significant role in innate and adaptive immunity against microbial pathogens.
  • Mast cell activators hold potential as effective vaccine adjuvants for conferring protective immunity.