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Updated: Jun 12, 2026

In vivo Imaging Method to Distinguish Acute and Chronic Inflammation
Published on: August 16, 2013
Peroxiredoxin: a central player in immune modulation
M W Robinson1, A T Hutchinson, J P Dalton
1Institute for the Biotechnology of Infectious Diseases (IBID), University of Technology Sydney (UTS), Ultimo, Sydney, NSW, Australia.
Abstract:
Peroxiredoxins (Prx) are a family of anti-oxidants that protect cells from metabolically produced reactive oxygen species (ROS). The presence of these enzymes in the secretomes of many parasitic helminths suggests they provide protection against ROS released by host immune effector cells. However, we recently reported that helminth-secreted Prx also contribute to the development of Th2-responses via a mechanism involving the induction of alternatively activated macrophages. In this review, we discuss the role helminth Prx may play in modulating the immune responses of their hosts.
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