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CSF baclofen levels after intrathecal administration in severe spasticity
B Sallerin-Caute1, Y Lazorthes, B Monsarrat
1Laboratoire de Pharmacie Galénique, Faculté des Sciences Pharmaceutiques, Toxicologie Fondamentales du CNRS, Toulouse, France.
European Journal of Clinical Pharmacology
|January 1, 1991
Summary
This study reports baclofen
Area of Science:
- Pharmacology
- Neuroscience
- Clinical Pharmacy
Background:
- Intrathecal baclofen is used for spasticity management.
- Understanding its pharmacokinetics is crucial for effective dosing.
Purpose of the Study:
- To characterize the pharmacokinetic parameters of intrathecal baclofen.
- To investigate inter-individual variability in baclofen CSF levels.
Main Methods:
- Reported pharmacokinetic parameters in cerebrospinal fluid (CSF).
- Administered intrathecal baclofen as a bolus to 4 patients.
- Measured CSF baclofen levels and correlated with H reflex.
Main Results:
- Significant inter-individual variability in pharmacokinetic parameters was observed.
- Elimination half-life ranged from 0.9 to 5 hours.
- Clearance varied from 0.013 to 0.08 L/h.
Conclusions:
- Intrathecal baclofen pharmacokinetics show considerable patient variability.
- Monitoring CSF baclofen levels alongside H reflex changes may optimize treatment.
- Further research needed to refine dosing strategies.