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Related Experiment Video

Updated: Jun 12, 2026

Lensless Fluorescent Microscopy on a Chip
11:23

Lensless Fluorescent Microscopy on a Chip

Published on: August 17, 2011

Lensfree on-chip imaging using nanostructured surfaces.

Bahar Khademhosseinieh, Ikbal Sencan, Gabriel Biener

    Applied Physics Letters
    |May 27, 2010
    PubMed
    Summary
    This summary is machine-generated.

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    We developed a lensfree microscopy technique using nanostructured surfaces for on-chip imaging. This method enables subpixel resolution imaging without lenses, ideal for compact fluorescent microscopes.

    Area of Science:

    • Optics and Photonics
    • Materials Science
    • Biomedical Engineering

    Background:

    • Traditional microscopy relies on lenses, limiting miniaturization and increasing cost.
    • On-chip imaging requires compact, high-resolution solutions for various applications.

    Purpose of the Study:

    • To introduce and validate a lensfree on-chip microscopy technique using nanostructured surfaces.
    • To demonstrate subpixel resolution imaging capabilities for compact microscopy.

    Main Methods:

    • Utilizing nanostructured thin metallic films for light modulation.
    • Employing a compressive sampling algorithm for object reconstruction.
    • Directly positioning the object onto the nanostructured surface for imaging.

    Main Results:

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    Lensless On-chip Imaging of Cells Provides a New Tool for High-throughput Cell-Biology and Medical Diagnostics
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    Lensless On-chip Imaging of Cells Provides a New Tool for High-throughput Cell-Biology and Medical Diagnostics

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    Last Updated: Jun 12, 2026

    Lensless Fluorescent Microscopy on a Chip
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    Lensless Fluorescent Microscopy on a Chip

    Published on: August 17, 2011

    Lensfree On-chip Tomographic Microscopy Employing Multi-angle Illumination and Pixel Super-resolution
    08:41

    Lensfree On-chip Tomographic Microscopy Employing Multi-angle Illumination and Pixel Super-resolution

    Published on: August 16, 2012

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    Lensless On-chip Imaging of Cells Provides a New Tool for High-throughput Cell-Biology and Medical Diagnostics

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    • Successful lensfree imaging on a chip without optical lenses.
    • Achieved subpixel level reconstruction of the object distribution.
    • Demonstrated the potential for creating compact lensfree fluorescent microscopes.

    Conclusions:

    • Nanostructured surfaces provide a viable platform for lensfree on-chip microscopy.
    • The developed modality offers a promising approach for miniaturized, high-resolution imaging systems.
    • This technique is particularly suitable for developing compact fluorescent microscopes.