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Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

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Related Experiment Video

Updated: Jun 12, 2026

Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection
04:04

Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection

Published on: August 15, 2025

A benign maxillary tumour with malignant features.

Rosario R Ricalde1, Aimee Caroline E Lim, Ramon Antonio B Lopa

  • 1Department of Otorhinolaryngology, University of the Philippines - Philippine General Hospital, Manila, Philippines. chitricalde@yahoo.com

Rhinology
|May 27, 2010
PubMed
Summary
This summary is machine-generated.

Hematoma-like mass of the maxillary sinus (HLMMS) can mimic aggressive tumors despite being benign. This review details HLMMS clinical features, diagnostic challenges, and surgical management, citing five patient cases.

Related Experiment Videos

Last Updated: Jun 12, 2026

Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection
04:04

Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection

Published on: August 15, 2025

Area of Science:

  • Otolaryngology
  • Pathology
  • Surgical Oncology

Background:

  • Non-specific biopsy findings like chronic inflammation, hemorrhage, and necrosis can mislead clinicians, particularly when patients exhibit symptoms of aggressive tumors.
  • Differentiating benign conditions from malignant neoplasms in the maxillary sinus presents a significant diagnostic challenge.

Observation:

  • This review focuses on the clinical presentation, diagnostic difficulties, and surgical treatment strategies for a specific benign maxillary mass with malignant-appearing features: hematoma-like mass of the maxillary sinus (HLMMS).
  • The study incorporates an analysis of five cases managed by the authors.

Findings:

  • HLMMS is characterized by clinical and pathological features that can mimic aggressive malignancy, leading to diagnostic uncertainty.
  • Effective surgical management is crucial for resolving this condition.

Implications:

  • Accurate diagnosis and appropriate surgical intervention are essential for managing patients with suspected aggressive maxillary tumors.
  • Understanding HLMMS aids in avoiding unnecessary aggressive treatments for benign conditions.