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Systematic review to support the development of nutrient reference intake values: challenges and solutions
Mei Chung1, Ethan M Balk, Stanley Ip
1Tufts Evidence-based Practice Center, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA02111, USA.
The American Journal of Clinical Nutrition
|May 28, 2010
Summary
Systematic reviews enhance transparency in setting nutrient reference values, like Dietary Reference Intakes (DRIs). Challenges in synthesizing extensive data were overcome through expert panels and tailored methods for improved evidence-based decision-making.
Area of Science:
- Nutrition Science
- Evidence Synthesis
- Public Health Policy
Background:
- Institute of Medicine (IOM) and World Health Organization recommended systematic reviews for updating nutrient reference values.
- Enhancing transparency and evidence distillation in decision-making processes for nutrient recommendations is crucial.
- Dietary Reference Intake (DRI) values require regular updates based on the latest scientific evidence.
Purpose of the Study:
- To describe the approach for integrating systematic reviews into the IOM process for updating nutrient reference values.
- To highlight challenges encountered during the systematic review process and present solutions.
- To inform future improvements in systematic reviews for nutrient assessment and reference value development.
Main Methods:
- Conducted a systematic review for the DRI Committee on vitamin D and calcium, building on IOM recommendations.
- Collaborated with a technical expert panel to prioritize outcomes and select relevant studies.
- Developed methods for utilizing existing systematic reviews, addressing limitations transparently.
- Employed tailored quality-assessment tools and transparent processes for translating study results.
Main Results:
- Successfully integrated systematic review methodology into the DRI update process.
- Overcame challenges related to synthesizing a large volume of primary studies across diverse outcomes.
- Established practical solutions for prioritizing, assessing, and synthesizing evidence.
- Demonstrated the feasibility of using systematic reviews for informing nutrient reference value deliberations.
Conclusions:
- Systematic reviews can significantly improve the comprehensiveness and transparency of nutrient reference value updates.
- The methods and solutions developed provide a framework for future systematic reviews in nutrition.
- Integrating systematic reviews enhances the scientific rigor and decision-making process for public health nutrition guidelines.
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