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Anti-cyclic citrullinated peptide and rheumatoid factor in HIV positive patients

Zeljko Romic1, Lovorka Derek, Vitomir Burek

  • 1Clinical Department for Laboratory Diagnostics, Dubrava University Hospital, Avenija Gojka Suska 6, 10000 Zagreb, Croatia.

Rheumatology International
|May 28, 2010
PubMed

Insights

Anti-cyclic citrullinated peptide (anti-CCP) and rheumatoid factor (RF) are significantly elevated in HIV patients compared to healthy individuals. Anti-CCP shows greater diagnostic potential for distinguishing these groups.

Area of Science:

  • Immunology
  • Rheumatology
  • Infectious Diseases

Background:

  • Rheumatological complications are common in HIV-positive patients, necessitating better diagnostic tools.
  • Anti-cyclic citrullinated peptide (anti-CCP) and rheumatoid factor (RF) are key laboratory markers for rheumatoid disorders.

Purpose of the Study:

  • To compare anti-CCP and RF levels between HIV-positive patients and a healthy control group.
  • To evaluate the diagnostic utility of anti-CCP and RF in identifying rheumatological issues in HIV.

Main Methods:

  • Sera from 45 HIV-positive patients and 35 healthy volunteers were analyzed for anti-CCP and RF.
  • Statistical analysis included chi-square test, Mann-Whitney test, and Receiver Operating Characteristic (ROC) curve analysis.

Main Results:

  • Both anti-CCP and RF levels were significantly higher in HIV-positive patients.
  • ROC analysis indicated that anti-CCP is a better discriminator between HIV patients and controls than RF.
  • Median anti-CCP levels in HIV patients exceeded the reference interval, while RF levels were within the manufacturer's suggested range.

Conclusions:

  • Anti-CCP and RF are significantly elevated in HIV-positive individuals.
  • Anti-CCP demonstrates superior performance over RF in differentiating HIV patients from healthy controls.
  • Further rheumatological evaluation of HIV-positive patients is warranted given these findings.

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