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Updated: Jun 12, 2026
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Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
Published on: March 30, 2019
MicroRNA as a new player in the cell cycle
Dongliang Chen1, Mary A Farwell, Baohong Zhang
1Department of Biology, East Carolina University, Greenville, North Carolina 27858, USA.
Journal of Cellular Physiology
|May 28, 2010
Summary
MicroRNAs (miRNAs) regulate cell cycles in various cells, including embryonic stem cells. Dysregulated miRNAs can lead to cancer, highlighting their therapeutic potential.
Area of Science:
- Molecular Biology
- Genetics
- Biochemistry
Background:
- MicroRNAs (miRNAs) are small, non-coding regulatory RNAs found across species.
- miRNAs play crucial roles in biological and metabolic processes.
- Emerging evidence implicates miRNAs in regulating protein-coding genes and cell cycle pathways.
Purpose of the Study:
- To review the functions of miRNAs in the cell cycle of differentiated and embryonic stem (ES) cells.
- To highlight the role of miRNAs in cell cycle regulation.
- To discuss the implications of miRNA dysregulation in carcinogenesis.
Main Methods:
- Literature review of studies on miRNA function in cell cycle regulation.
- Analysis of research on differentiated cells and embryonic stem cells.
- Examination of the link between aberrant miRNA expression and cancer.
Main Results:
- miRNAs are key regulators of the cell cycle in both differentiated and ES cells.
- Specific miRNAs influence progression through cell cycle checkpoints.
- Aberrant expression patterns of cell-cycle-related miRNAs are observed in various cancers.
Conclusions:
- miRNAs are critical for normal cell cycle progression.
- Dysregulation of miRNAs in the cell cycle is linked to carcinogenesis.
- Cell-cycle-related miRNAs represent promising therapeutic targets for cancer treatment.
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