Related Experiment Video
Updated: Jun 12, 2026
06:15
Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Summary
Orbital lymphomas, cancers affecting the eye socket, are increasingly common. This study analyzes treatment outcomes for 14 patients, finding low-grade B-cell lymphomas generally have better survival rates.
Area of Science:
- Ophthalmology
- Oncology
- Pathology
Context:
- Orbital lymphomas represent a growing oncological concern, affecting both immunocompromised and immunocompetent individuals.
- Their increasing incidence highlights the need for effective diagnostic and therapeutic strategies.
Purpose:
- To analyze the clinical experience and treatment outcomes of orbital lymphomas at a specific university hospital between 1997 and 2008.
- To evaluate the efficacy of surgical and diagnostic approaches for orbital lymphoma.
Summary:
- The study reviewed 14 patients (13 primary orbital lymphomas, 1 systemic) with a mean age of 65.6 years, predominantly unilateral lesions.
- Common symptoms included exophthalmos and eyelid masses. Diagnosis involved neuro-ophthalmology, CT, and MRI. Surgical approaches varied, with gross total resection achieved in 6 cases.
- Histopathology revealed mostly low-grade B-cell small lymphocytic non-Hodgkin's lymphoma. Long-term survival (>5 years) was observed in 4 primary orbital lymphoma cases.
Impact:
- This research provides valuable insights into the management and prognosis of orbital lymphomas based on a decade of clinical data.
- Findings underscore the importance of early diagnosis and appropriate surgical and histological evaluation for optimizing patient outcomes in orbital oncology.
Related Concept Videos
01:15Secondary Lymphoid Organs
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
01:16Primary Lymphoid Organs
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
01:18Lymphoid Cells and Tissues
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
01:18Electron Orbital Model
Orbitals are the areas outside of the atomic nucleus where electrons are most likely to reside. They are characterized by different energy levels, shapes, and three-dimensional orientations. The location of electrons is described most generally by a shell or principal energy level, then by a subshell within each shell, and finally, by individual orbitals found within the subshells.The first shell is closest to the nucleus, and it has only one subshell with a single spherical orbital called the...
02:44Atomic Orbitals
An atomic orbital represents the three-dimensional regions in an atom where an electron has the highest probability to reside. The radial distribution function indicates the total probability of finding an electron within the thin shell at a distance r from the nucleus. The atomic orbitals have distinct shapes which are determined by l, the angular momentum quantum number. The orbitals are often drawn with a boundary surface, enclosing densest regions of the cloud.
01:28Graves' Disease I: Introduction
Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...