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White blood cell count and cardiovascular biomarkers of atherosclerosis

Yui Sekitani1, Naomi Hayashida, Koichiro Kadota

  • 1Department of Radiation Epidemiology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
|May 29, 2010
PubMed

Insights

White blood cell (WBC) count showed a weak association with cardio-ankle vascular index (CAVI) in men but not women. No significant correlation was found between WBC count and carotid intima-media thickness (CIMT).

Area of Science:

  • Cardiovascular disease research
  • Inflammation and atherosclerosis

Background:

  • White blood cell (WBC) count is a marker of inflammation.
  • Inflammation plays a role in the development of atherosclerosis.
  • Atherosclerotic parameters like cardio-ankle vascular index (CAVI) and carotid intima-media thickness (CIMT) are indicators of vascular health.

Purpose of the Study:

  • To investigate the association between white blood cell (WBC) count and atherosclerotic parameters.
  • To examine the relationship between WBC count, CAVI, and CIMT in the general population.

Main Methods:

  • A study involving 3738 Japanese participants.
  • Investigated the relationship between WBC count and metabolic syndrome components.
  • Assessed CAVI and CIMT as measures of atherosclerosis.

Main Results:

  • WBC count weakly correlated with CAVI in men (beta = 0.61, p = 0.043), but not in women (beta = 0.35, p = 0.17).
  • WBC count did not correlate with CIMT in either men or women (p = 0.41 and p = 0.71, respectively).

Conclusions:

  • WBC count showed associations with lipids, blood pressure, and body mass index.
  • Correlations between WBC count and CAVI/CIMT were weak or absent in this population.
Abstract

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