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Updated: Jun 12, 2026
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An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
Effects of estrogens on atherogenesis
Genovefa Kolovou1, Vasiliki Giannakopoulou, Yannis Vasiliadis
11st Cardiology Department, Onassis Cardiac Surgery Center, 356 Sygrou Avenue, Athens, Greece. genovefa@kolovou.com
Current Vascular Pharmacology
|May 29, 2010
Summary
Estrogen offers protection against atherosclerosis and cardiovascular events in women. This protective effect diminishes with age, highlighting the role of hormone status in cardiovascular health.
Area of Science:
- Cardiovascular Science
- Endocrinology
- Pathology
Background:
- Cardiovascular disease remains a leading cause of death globally.
- Myocardial infarction is less common in premenopausal women compared to men, linked to estrogen levels.
- This protective effect of estrogen diminishes in postmenopausal women.
Purpose of the Study:
- To review the role of estrogens in atherogenesis.
- To discuss factors influencing atherosclerosis development.
- To explore the impact of hormone replacement therapy.
Main Methods:
- Review of existing clinical trials and research models.
- Analysis of biological and cellular events in atherogenesis.
- Examination of environmental and genetic factors.
Main Results:
- Estrogens demonstrate a protective effect against atherogenesis and atherosclerotic plaque formation.
- Estrogen's influence on various stages of plaque development is significant.
- Age-related hormonal changes impact cardiovascular risk in women.
Conclusions:
- Estrogen plays a crucial role in cardiovascular protection for women.
- Understanding estrogen's effects is key to managing cardiovascular disease risk.
- Further research into hormone replacement therapy's cardiovascular implications is warranted.
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