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Updated: Jun 12, 2026
08:14
MicroRNA Based Liquid Biopsy: The Experience of the Plasma miRNA Signature Classifier (MSC) for Lung Cancer Screening
Published on: October 26, 2017
Screening for lung cancer: are we there yet?
Maurizio V Infante1, Jesper H Pedersen
1Department of Thoracic Surgery, Istituto Clinico Humanitas, Rozzano, Milan, Italy. maurizio.infante@humanitas.it
Current Opinion in Pulmonary Medicine
|May 29, 2010
Summary
Lung cancer screening with low-dose computed tomography (LDCT) shows promise for early detection. However, definitive mortality reduction benefits require further data from ongoing randomized trials.
Area of Science:
- Pulmonology
- Radiology
- Oncology
Background:
- Lung cancer screening with low-dose spiral computed tomography (LDCT) identifies early-stage disease in 50-85% of cases.
- Resected stage I lung cancer exhibits a survival rate exceeding 90%.
Purpose of the Study:
- To provide an update on recent advancements in lung cancer screening knowledge.
- To review progress in detection systems, nodule evaluation, cost-effectiveness, and surgical options.
Main Methods:
- Review of recent findings in lung cancer screening research.
- Analysis of technical and collateral aspects of LDCT screening.
- Inclusion of early follow-up data from one randomized trial comparing LDCT to clinical review.
Main Results:
- Novelties include improved detection systems, nodule evaluation protocols, and cost-effectiveness strategies.
- Insights into lung cancer biology and promotion of minimally invasive surgical options are highlighted.
- Early follow-up data from one trial suggest a potentially smaller than expected impact of LDCT on mortality.
Conclusions:
- Definitive conclusions on mortality reduction await results from ongoing randomized trials in Europe and the USA.
- Lung cancer screening research contributes valuable knowledge applicable to other smoking-related diseases.
- Ongoing research enhances understanding of lung cancer biology.
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