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Related Experiment Videos

Mal de Meleda-like palmoplantar keratoderma.

T Iio1, S Shiraishi, K Sayama

  • 1Department of Dermatology, University of Ehime School of Medicine, Japan.

The Journal of Dermatology
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

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Severe palmoplantar keratoderma, mimicking mal de Meleda, was observed in a Japanese man. Oral etretinate treatment effectively improved the patient's keratoderma symptoms.

Area of Science:

  • Dermatology
  • Genetics
  • Oncology

Background:

  • Palmoplantar keratoderma is a group of inherited skin disorders characterized by thickening of the palms and soles.
  • Mal de Meleda is a rare autosomal recessive disorder presenting with severe palmoplantar keratoderma and other symptoms.
  • Squamous cell carcinoma can arise in chronic skin conditions, including keratoderma.

Observation:

  • A 38-year-old Japanese man presented with severe palmoplantar keratoderma extending to dorsal aspects with erythematous rims.
  • The patient had a history of spontaneous toe amputations and right lower leg amputation due to squamous cell carcinoma on the right sole.
  • Clinical presentation suggested mal de Meleda, but lacked consanguinity and epidermal granular layers.

Findings:

  • The patient's severe palmoplantar keratoderma showed some similarities to mal de Meleda but with distinct epidermal features.

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  • The development of squamous cell carcinoma in the affected sole highlights a potential complication of severe keratoderma.
  • Treatment with oral etretinate led to significant improvement in the patient's keratoderma.

    • Implications:

    • This case expands the clinical spectrum of palmoplantar keratoderma and its differential diagnosis.
    • Early recognition and management of complications like squamous cell carcinoma are crucial in patients with severe keratoderma.
    • Etretinate may be a viable therapeutic option for managing severe palmoplantar keratoderma, warranting further investigation.