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Updated: Jun 12, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
Published on: June 15, 2019
Corticosteroids in sepsis: pathophysiological rationale and the selection of patients
Jorge Ibrain Figueira Salluh1, Fernando Augusto Bozza, André Miguel Japiassú
1Intensive Care Unit and Post-graduate Program, Instituto Nacional de Câncer, Rio de Janeiro, Brazil. jorgesalluh@yahoo.com.br
Abstract:
Corticosteroids have been proposed for decades as adjunctive therapy of severe infections. These drugs have complex mechanisms of action involving anti-inflammatory and vasoactive properties. However, due to discordant results from clinical studies, the use of corticosteroids to treat patients with severe infections is still a matter of intense debate in the scientific and medical community. In the present article, we review the underlying mechanisms related to the potential benefits of corticosteroids and their impact on clinical management of severe sepsis.
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