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Association of the OLR1 rs11053646 Polymorphism with Type 2 Diabetes Risk in Saudi Adults
1Department of Rehabilitation Sciences, College of Applied Medical Sciences, King Saud University, 10219 Riyadh, Saudi Arabia.
Endocrine, Metabolic & Immune Disorders Drug Targets
|August 11, 2026
Summary
The oxidized low-density lipoprotein receptor 1 (OLR1) rs11053646 single nucleotide polymorphism (SNP) shows no significant association with type 2 diabetes (T2D) risk in Saudi adults. Further research with larger cohorts is needed to confirm these findings on T2D risk factors.
Area of Science:
- Genetics
- Metabolic Disorders
- Epidemiology
Background:
- Genetic variations in oxidative stress and lipid metabolism are linked to type 2 diabetes (T2D).
- The specific role of the OLR1 rs11053646 single nucleotide polymorphism (SNP) in T2D susceptibility within the Saudi population is not well-established.
- This study investigated the potential association between the OLR1 rs11053646 SNP and T2D risk.
Purpose of the Study:
- To determine if the OLR1 rs11053646 SNP is associated with an increased risk of developing type 2 diabetes in Saudi adults.
- To contribute to understanding the genetic underpinnings of T2D in a specific ethnic cohort.
Main Methods:
- A case-control study involving 143 Saudi adults (79 T2D cases, 64 controls) in Riyadh.
- Genotyping of the OLR1 rs11053646 SNP using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP).
- Logistic regression analysis, adjusted for age, sex, and body mass index, was employed to assess the association with T2D risk.
Main Results:
- Genotype distribution in controls adhered to Hardy-Weinberg equilibrium.
- The GG genotype was most common; the CC genotype was not observed.
- No statistically significant difference in genotype or allele frequencies was found between T2D cases and controls.
- Adjusted analyses revealed no significant association between the OLR1 rs11053646 SNP and T2D risk (OR=0.41, p=0.14).
Conclusions:
- The OLR1 rs11053646 SNP does not appear to be a significant risk factor for type 2 diabetes in the Saudi adults studied.
- The absence of the CC genotype and the relatively small sample size may have limited the study's power to detect subtle associations.
- Larger, well-powered studies are recommended to definitively ascertain the role of this SNP in T2D susceptibility in this population.
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