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A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood

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Published on: April 28, 2016

Ghrelin in the human myometrium.

Margaret O'Brien¹, Padraig Earley, John J Morrison

¹National Centre for Biomedical and Engineering Science, Orbsen Building, National University of Ireland Galway, University Road, Galway, Ireland. margaret.obrien@nuigalway.ie

Reproductive Biology and Endocrinology : RB&E

|June 1, 2010

Summary

Ghrelin and its receptor are present in the human myometrium, with expression changing during pregnancy and labor. Myometrial ghrelin may play a role in maintaining uterine relaxation during pregnancy.

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Area of Science:

Reproductive biology
Endocrinology
Molecular biology

Background:

Ghrelin, a peptide hormone, influences various physiological processes including growth hormone release and appetite.
Previous research indicated ghrelin's inhibitory effect on human myometrial contractility in vitro.
The study investigates ghrelin system components in human myometrium across different physiological states.

Purpose of the Study:

To examine the expression of ghrelin, its receptor (GHS-R1), and processing enzymes (GOAT, PC1/3) in human myometrium.
To understand how expression levels change during pregnancy, labor, and in the non-pregnant state.
To investigate the modulation of ghrelin and GHS-R1 in cultured myometrial cells.

Main Methods:

Analysis of mRNA and protein from human myometrium and hTERT-HM cells.
Techniques included real-time RT-PCR, western blotting, and fluorescence microscopy.
Evaluation of beta-Estradiol and LPS effects on hTERT-HM gene expression.

Main Results:

Ghrelin, GHS-R1, GOAT, and PC1/3 are expressed in human myometrium.
Ghrelin and GHS-R1 expression decreased during labor, while GOAT expression increased during non-laboring pregnancy.
PC1/3 expression decreased in late pregnancy and labor compared to the non-pregnant state.

Conclusions:

Ghrelin processing occurs in the myometrium, with altered expression during pregnancy and labor.
Increased GOAT expression suggests potential myometrial ghrelin acylation, and PC1/3 aids pro-ghrelin processing.
Myometrial ghrelin likely contributes to uterine relaxation during pregnancy, with LPS and beta-Estradiol influencing its regulation.