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Increases in urinary creatinine and blood pressure during early pregnancy in pre-eclampsia

Koichi Kuromoto1, Mikio Watanabe, Kazushige Adachi

  • 1Department of Biomedical Informatics, Division of Health Sciences, Graduate School of Medicine, Osaka University, Japan.

Annals of Clinical Biochemistry
|June 1, 2010
PubMed

Insights

Predicting pre-eclampsia (PE) early is crucial. Combining urinary creatinine and systolic blood pressure in the first trimester, or urinary inorganic phosphorus/creatinine and systolic blood pressure in the second trimester, effectively predicts PE.

Area of Science:

  • Obstetrics and Gynecology
  • Clinical Chemistry
  • Maternal-Fetal Medicine

Background:

  • Pre-eclampsia (PE) poses risks during pregnancy.
  • Early prediction of PE is vital for timely intervention.
  • Identifying reliable predictive markers remains a research priority.

Purpose of the Study:

  • To investigate urinary biochemical markers and blood pressure (BP) for predicting PE.
  • To assess the utility of specific urinary parameters combined with BP measurements.
  • To establish predictive models for PE development during pregnancy.

Main Methods:

  • A case-control study involving 25 PE patients and 172 normotensive pregnant women.
  • Measurement of twelve urinary biochemical parameters and systolic/diastolic BP.
  • Analysis using multiple logistic regression and receiver operator characteristic (ROC) curves.

Main Results:

  • Combination of urinary creatinine (Cr) and systolic BP (SBP) in the first trimester predicted PE (AUC=0.85).
  • Combination of urinary inorganic phosphorus/Cr (IP/Cr) and SBP in the second trimester predicted PE (AUC=0.91).
  • First-trimester prediction achieved 75% sensitivity and 95% specificity with specific cut-offs.

Conclusions:

  • Urinary Cr and SBP in early pregnancy are useful for PE prediction.
  • Urinary IP/Cr and SBP in mid-pregnancy are valuable for PE prediction.
  • Combined biomarkers offer enhanced accuracy for PE risk assessment.
Abstract

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