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Updated: Jun 12, 2026

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
Published on: March 7, 2019
[Zerebrale Amyloidangiopathie : Cerebral amyloid angiopathy]
1Neurologische Klinik HELIOS-Kliniken Schwerin, Schwerin, Deutschland. frank.block@helios-kliniken.de
Abstract:
Cerebral amyloid angiopathy (CAA) is defined by the accumulation of β-amyloid in the walls of cortical arteries. The risk factors of CAA include advanced age and the presence of certain alleles of apolipoprotein E. CAA mostly remains asymptomatic, but the classical manifestation is intracerebral hemorrhage. A definite diagnosis can only be made on the basis of histopathological examination. Detection of lobar hemorrhages and lobar microhemorrhages in imaging investigations support the diagnosis of CAA as long as other causes can be excluded.
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