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Related Experiment Video

Updated: Jun 12, 2026

Electric Cell-Substrate Sensing for Real-Time Evaluation of Metal-Organic Framework Toxicological Profiles
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Electric Cell-Substrate Sensing for Real-Time Evaluation of Metal-Organic Framework Toxicological Profiles

Published on: May 26, 2023

Testing metal-oxide nanomaterials for human safety.

Robert Landsiedel1, Lan Ma-Hock, Alexandra Kroll

  • 1BASF SE 67056 Ludwigshafen, Germany. wendel.wohlleben@basf.com

Advanced Materials (Deerfield Beach, Fla.)
|June 1, 2010
PubMed
Summary

The biological impact of nanomaterials depends on multiple properties, not just one. Understanding these factors helps create safer nanomaterials for various applications.

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Area of Science:

  • Materials Science
  • Toxicology
  • Nanotechnology

Background:

  • Nanomaterials exhibit different biological effects than their bulk counterparts.
  • Physico-chemical characterization and biological interaction studies are crucial for nanomaterial safety assessment.

Purpose of the Study:

  • To review the physico-chemical properties of metal oxide and carbon nanomaterials.
  • To correlate these properties with biological impact and hazard potential.

Main Methods:

  • Review of existing rat inhalation and cell culture studies.
  • Analysis of nanomaterial properties including reactive oxygen species generation, shape, size, solubility, and crystalline phase.

Main Results:

  • Hazard potential is a composite of multiple physico-chemical properties.

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In Situ Detection and Single Cell Quantification of Metal Oxide Nanoparticles Using Nuclear Microprobe Analysis
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In Situ Detection and Single Cell Quantification of Metal Oxide Nanoparticles Using Nuclear Microprobe Analysis

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Toxicity Study of Zinc Oxide Nanoparticles in Cell Culture and in Drosophila melanogaster
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Toxicity Study of Zinc Oxide Nanoparticles in Cell Culture and in Drosophila melanogaster

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Last Updated: Jun 12, 2026

Electric Cell-Substrate Sensing for Real-Time Evaluation of Metal-Organic Framework Toxicological Profiles
04:53

Electric Cell-Substrate Sensing for Real-Time Evaluation of Metal-Organic Framework Toxicological Profiles

Published on: May 26, 2023

In Situ Detection and Single Cell Quantification of Metal Oxide Nanoparticles Using Nuclear Microprobe Analysis
14:53

In Situ Detection and Single Cell Quantification of Metal Oxide Nanoparticles Using Nuclear Microprobe Analysis

Published on: February 3, 2018

Toxicity Study of Zinc Oxide Nanoparticles in Cell Culture and in Drosophila melanogaster
06:47

Toxicity Study of Zinc Oxide Nanoparticles in Cell Culture and in Drosophila melanogaster

Published on: September 19, 2019

  • A hazard ranking was established: multi-walled carbon nanotubes >> CeO(2), ZnO > TiO(2) > functionalized SiO(2) > SiO(2), ZrO(2), carbon black.

    • Conclusions:

    • Enhanced understanding of nanomaterial biophysical properties and cellular effects improves safety testing.
    • This knowledge aids in the selection and production of safer nanomaterials.