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Published on: May 31, 2020
Yellow fever: a reemerging threat.
Christina L Gardner1, Kate D Ryman
1Center for Vaccine Research, Department of Microbiology and Molecular Genetics, University of Pittsburgh, PA 15261, USA.
Clinics in Laboratory Medicine
|June 2, 2010
Summary
Yellow fever (YF) is a serious viral disease transmitted by mosquitoes in Africa and the Americas. This review covers YF history, diagnosis, treatment, and vaccines, highlighting its reemerging importance.
Area of Science:
- Virology
- Epidemiology
- Public Health
Background:
- Yellow fever (YF) is a mosquito-borne viral disease endemic to tropical Africa and the Americas.
- Yellow fever virus (YFV) poses a significant threat due to its potential for fatal hemorrhagic disease and devastating epidemics.
- Despite vaccination efforts, the risk of major YF epidemics is increasing, particularly in urban areas.
Purpose of the Study:
- To provide a comprehensive review of Yellow fever virus (YFV).
- To cover the history, microbiology, epidemiology, clinical presentation, diagnosis, and treatment of YF.
- To discuss vaccines developed for YF prevention and control.
Main Methods:
- Literature review of historical and current data on YF.
- Synthesis of information on YFV transmission and disease characteristics.
- Analysis of vaccination strategies and their effectiveness.
Main Results:
- YFV remains a significant public health concern with increasing epidemic risk.
- Effective vaccines exist, but challenges in widespread implementation persist.
- Understanding YF's multifaceted aspects is crucial for control.
Conclusions:
- Yellow fever is a reemerging disease requiring ongoing vigilance and intervention.
- Comprehensive knowledge of YFV is essential for effective disease management.
- Vaccination remains a cornerstone of YF prevention, alongside vector control.
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