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Published on: April 14, 2014
Correlation between functional and structural assessments of the optic nerve and retina in multiple sclerosis
C Almarcegui1, I Dolz, V Pueyo
1Hospital Miguel Servet, Neurofisiologia Clinica, paseo Isabel la Catolica 1-3, 50009 Zaragoza, Spain. idolz@salud.aragon.es
Objective:
The aim of this study was to evaluate the correlation between functional eye examinations (visual evoked potentials: VEPs; pattern electroretinogram: PERG) and structural measurements of the optic nerve (optical coherence tomography: OCT; scanning laser polarimetry: GDx) in patients with multiple sclerosis (MS).
Methods:
Patients with definite MS and disease-free controls were enrolled in the study. VEPs and PERG were recorded in all subjetcs. Ophthalmologic examination, including visual acuity, visual field determination, OCT and GDx were performed.
Results:
Nineteen MS patients and 19 age- and sex-matched controls were included in the study. Significant differences between both groups were observed with respect to VEP (P100 latency and amplitude), PERG (N95 amplitude and N95/P50 ratio) and OCT parameters (average, temporal and macular volume). There were a statistically significant correlation between VEP or PERG parameters and OCT or GDx results.
Conclusions:
In MS patients, axonal loss in ganglion cells can be detected with OCT and GDx. PERG is a useful complementary tool to identify this damage.
