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Functional Evaluation of the Visual Pathway in Patients with Multiple Sclerosis Using a Multifunction Stimulator

M Satue1,2, L Jarauta3, J Obis1,2

  • 1Ophthalmology Department, Miguel Servet University Hospital, Zaragoza, Spain.

Journal of Ophthalmology
|October 24, 2019
PubMed
Summary

The Monpack One vision monitor effectively detects visual dysfunction in multiple sclerosis (MS) patients. It correlates retinal structure with functional measurements, aiding in the assessment of axonal damage.

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Area of Science:

  • Ophthalmology
  • Neurology
  • Medical Devices

Background:

  • Multiple sclerosis (MS) is a demyelinating disease affecting the central nervous system, often causing visual pathway impairment.
  • Early detection of visual dysfunction in MS is crucial for monitoring disease progression and treatment efficacy.

Purpose of the Study:

  • To evaluate the Monpack One vision monitor's ability to detect visual function alterations in MS patients.
  • To assess the correlation between retinal structural parameters and functional measurements obtained with the Monpack One.

Main Methods:

  • A cross-sectional study included 48 MS patients and 46 healthy controls.
  • Functional visual pathway evaluation included low-contrast visual acuity (LCVA), contrast sensitivity vision (CSV), automated perimetry, multifocal visual evoked potentials (mfVEPs), and pattern electroretinogram (ERG) using the Monpack One.
  • Retinal structural measurements were performed using optical coherence tomography (OCT).

Main Results:

  • MS patients showed significantly reduced LCVA and CSV across various spatial frequencies.
  • All tested visual field parameters were significantly altered in MS patients compared to controls.
  • mfVEPs revealed reduced P100 waveform amplitude in specific retinal areas of MS patients; pattern ERG showed no significant differences.
  • Significant correlations were found between inner macular structural measurements and contrast sensitivity/perimetry indexes.

Conclusions:

  • The Monpack One effectively detects visual dysfunction in patients with multiple sclerosis.
  • This device offers a rapid and valuable tool for comprehensive evaluation of axonal damage in MS.