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Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery
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A highly effective gene delivery vector--hyperbranched poly(2-(dimethylamino)ethyl methacrylate) from in situ
Ben Newland1, Hongyun Tai, Yu Zheng
1Network of Excellence for Functional Biomaterials, National University of Ireland Galway, Galway, Ireland.
Abstract:
A hyperbranched 2-(dimethylamino)ethyl methacrylate (DMAEMA) based polymer has been synthesised by a one-pot in situ deactivation enhanced atom transfer radical polymerisation (DE-ATRP); it exhibits much higher transfection ability than linear poly(DMAEMA) and is comparable to the well known branched poly(ethylene imine) (PEI) and the SuperFect dendrimer but with lower cytotoxicity.
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