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Induced endogenous autotoxicity in Camptotheca.

Shiyou Li¹, Ping Wang, Wei Yuan

¹National Center for Pharmaceutical Crops, Arthur Temple College of Forestry and Agriculture, Stephen F Austin State University, Nacogdoches, TX 75962, USA. lis@sfasu.edu

Frontiers in Bioscience (Elite Edition)

|June 3, 2010

Summary

Plants can experience autotoxicity from their own toxic compounds, like camptothecin. Pruning can trigger this, causing abnormal growth, but it resolves when the toxic compound levels decrease.

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Area of Science:

Plant physiology
Biochemistry
Developmental biology

Background:

Plants produce toxic secondary metabolites for defense.
Camptotheca plants tolerate high levels of endogenous camptothecin.
Pruning typically promotes lateral growth.

Purpose of the Study:

To investigate if plants can be harmed by their own toxic compounds (autotoxicity).
To determine the effect of pruning on endogenous camptothecin levels and plant morphology.
To explore the role of auxin in camptothecin-induced autotoxicity.

Main Methods:

Observing morphological changes in Camptotheca plants after decapitation pruning.
Measuring endogenous camptothecin levels in pruned and control plants.
Applying exogenous auxin to a high-camptothecin yielding mutant.

Main Results:

Decapitation pruning induced autotoxicity, leading to abnormal morphogenesis (serrated leaves, fasciated stems).
Abnormal growth correlated with elevated camptothecin levels post-pruning.
Autotoxicity symptoms resolved when camptothecin levels returned to normal.
Exogenous auxin application normalized a high-yield mutant's phenotype.

Conclusions:

Plants are not always immune to their endogenous toxic secondary metabolites.
Pruning can induce autotoxicity in Camptotheca, mediated by camptothecin.
Auxin may play a role in triggering this endogenous autotoxicity.