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Published on: December 11, 2017
Stent-based, off-pump creation of an apico-aortic conduit
Jan Spillner1, Nima Hatam, Andrea Amerini
1Clinic for Cardiothoracic Surgery, University Hospital RWTH Aachen, Pauwelsstr 30, D-52074 Aachen, Germany. jspillner@ukaachen.de
Frontiers in Bioscience (Elite Edition)
|June 3, 2010
Summary
This study demonstrates the feasibility of creating an apico-aortic conduit (AAC) off-pump using a novel stent-based device in pigs. The technique showed promising results for future cardiac surgery applications.
Area of Science:
- Cardiovascular Surgery
- Biomedical Engineering
Background:
- Apico-aortic conduit (AAC) offers an alternative for patients with aortic valve stenosis and severe comorbidities.
- Current off-pump AAC creation methods require further refinement.
Purpose of the Study:
- To assess the feasibility of an off-pump AAC creation using a novel stent-based device.
- To evaluate the safety and efficacy of this new technique in an animal model.
Main Methods:
- A new self-expandable, stent-equipped prosthesis and a specialized sheath were designed.
- The device was tested in six pigs, with hemodynamic and echocardiographic assessments.
- MRI was performed in three animals; autopsies were conducted post-procedure.
Main Results:
- The procedure was performed without significant blood loss, air embolism, or hemodynamic compromise.
- Successful creation of an AAC capable of handling total cardiac output was achieved.
- Autopsy confirmed excellent prosthesis anchorage with no significant intracavitary injury or thrombosis.
Conclusions:
- The study proves the feasibility of a stent-based, off-pump creation of an AAC.
- This innovative approach shows potential for broader applications in cardiac interventions.
